Some are Calling it a “Breakthrough” in Alzheimer’s Research

With estimates of up to 5.8 million people in the U.S. living with Alzheimer’s, any news about a possible breakthrough regarding the cause of the disease is exciting. The Medical News Today reports on an interesting study out of Australia, which suggests it has identified a likely cause of Alzheimer’s disease, that some are calling a “breakthrough.” 

Dr. John Mamo, Ph.D., the lead author of the study, and distinguished professor and director of the Curtin Health Innovation Research Institute at Curtin University in Perth, Australia, explains the research’s conclusion. He starts by citing the fact that up to now, one of the problems in the fight against Alzheimer’s, is we have not known the cause of the disease. Dr. Mamo says, “This study shows that exaggerated abundance in blood of potentially toxic fat-protein complexes can damage microscopic brain blood vessels called capillaries and, thereafter, leak into the brain, causing inflammation and brain cell death.”

The research was done with test mice whose livers were genetically modified to produce human amyloid-beta, which some believe may be a cause of Alzheimer’s. The control group had no genetic modifications. During the blind study, scientists “found when the amyloid-beta proteins made in the liver of the test mice combined with fats and traveled to the brain, they interfered with the proper functioning of the brain’s microscopic blood vessels, or capillaries.” 

Dr. Mamo says they found the inflammation was also associated with marked degeneration in the brain cells of the mice in the test group when examined under a microscope. Also when putting the mice through a series of cognitive function tests, researchers found the test mice performed approximately half as well as the control group at retention of learning.

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Source: medicalnewstoday.com/articles/likely-cause-of-alzheimers-identified-in-new-study?utm_source=Sailthru%20Email&utm_medium=Email&utm_campaign=dedicated&utm_content=2021-10-03&apid=32549197&rvid=e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855